Rab 12 kD
نویسندگان
چکیده
منابع مشابه
Rab GTPase localization and Rab cascades in Golgi transport.
Rab GTPases are master regulators of membrane traffic. By binding to distinct sets of effector proteins, Rabs catalyse the formation of function-specifying membrane microdomains. They are delivered to membranes by a protein named GDI (guanine-nucleotide-dissociation inhibitor) and are stabilized there after nucleotide exchange by effector binding. In the present mini-review, I discuss what we k...
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Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in eukaryotic cells, play an important role in cancer. We analysed the deregulation at the transcriptional level of the genes encoding Rab proteins and Rab-interacting proteins in bladder cancer pathogenesis, distinguishing between the two main progression pathways so far identified in bladder cancer: the Ta ...
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The kidney disease (kd) mutation was transferred to a C57BL/6 (B6) background by selection for closely linked microsatellite markers. The resulting congenic strain, B6.kd, was mated with partners homozygous for targeted mutations of CD4, CD8, CD28, IL-2, recombinase-activating gene-1 (Rag-1), ICAM-1, or beta(2)-microglobulin. In most of the resulting double mutants, kidney disease occurred as r...
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Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular tr...
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T iming the breakdown Before chromosomes can go their separate ways during mitosis, the nuclear envelope has to dissolve. As Hebbar et al. reveal, breakdown of the membrane might infl uence the fate of cells in the developing brain by controlling when they divide. The ventricular zone is the developing brain's maternity ward, where stem cells give birth to neurons and other cell types. Within t...
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ژورنال
عنوان ژورنال: Science
سال: 1989
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.2686025